Preliminary Program

 

Monday Tuesday  Wednesday

Monday, 23 September

Axon 1+2
Opening 
11:00 - 11:20 Welcome to the Max Delbrück Center for Molecular Medicine, Berlin-Buch
11:20 - 11:30 GSCN Annual Conference 2019
Hartmut Geiger, President GSCN
11:30 - 12:15 
Keynote lecture I
K1 - New insights into Xist-mediated processes of X-chromosome dosage compensation - a paradigm for epigenetic regulation in stem cells
Kathrin Plath, UCLA, Los Angeles, US
(Chair: Baris Tursun)
12:15 - 13:00 Keynote lecture II
K2 - Human pluripotent stem cell-derived gastrointestinal organoids as new models to study human organ development, digestive diseases and diabetes
James Wells, Cincinnati Children’s Hospital Medical Center, US
(Chair: Alexander Meissner)
13:00 - 14:30
Lunch break / Industry exhibition
14:30 - 16:00 Concurrent scientific working group session I
Axon 1
14:30 - 16:00
14:30 - 15:00


15:00 - 15:15


15:15 - 15:30


15:30 - 15:45


15:45 - 16:00
Pluripotency & reprograming
(Chairs: Micha Drukker / Mathias Treier)
T01 - Differential regulation of OCT4 targets facilitates reacquisition of pluripotency
Alexander Meissner, MPI for Molecular Genetics, Berlin
T02 - Control of epiblast self-organization in naïve and paused states of pluripotency
Ivan Bedzhov, MPI for Molecular Biomedicine, Münster
T03 - Identification of X-linked genes that drive sex differences in mouse embryonic stem cells
Oriana Genolet, MPI for Molecular Genetics, Berlin
T04 - Reprogramming enriches for somatic cell clones with small scale mutations in cancer-related genes
Maike Kosanke, Hannover Medical School (MHH)
T05 - Multi-omics analysis of human neural development using induced neural plate border stem cells
Jasper Panten, German Cancer Research Center (DKFZ), Heidelberg
Axon 2
14:30 - 16:00
14:30 - 15:00



15:00 - 15:15


15:15 - 15:30


15:30 - 15:45


15:45 - 16:00
Stem cells in regenerative therapies: mesenchymal stromal cells
(Chairs: Ulrich MartinDirk Strunk)
T06 - Expansion of human bone marrow-derived mesenchymal stromal cells with gamma irradiated pooled human platelet lysate
Richard Schäfer, DRK Blutspendedienst Baden-Württemberg - Hessen, Frankfurt
T07 - A fully automated pipeline for the large-scale production of mesenchymal stem cells (MSC)
Ferdinand Biermann, Fraunhofer IPT, Aachen
T08 - Differentiation of induced pluripotent stem cells towards mesenchymal stromal cells is triggered by flat substrates
Roman Goetzke, RWTH Aachen
T09 - In vitro generation of therapeutically active vascular wall-typical mesenchymal stem cells from human fibroblasts
Jennifer Steens, University hospital Essen
T10 - Wnt5a expressed by osteolineage niche cells regulates actin-assembly, mitochondrial function and regenerative capacity of hematopoietic stem cells
Theresa Sippenauer, TU Munich
Dendrit 2+3
14:30 - 16:00
14:35 - 14:55


14:55 - 15:15

15:15 - 15:30

15:30 - 15:45


15:45 - 16:00
Computational stem cell biology
(Chairs: Georg Fuellen / Carsten Marr)
T11 - Systems biology and medicine in the genomics era: challenges in data processing, analysis, and integration
Altuna Akalin, Max-Delbrück-Center, Berlin
T12 - tba
Antonio del Sol, University of Luxembourg
T13 - Stem cell identity and lineage: insights from network theory
Philip Greulich, University of Southampton, UK
T14 - BART-Seq: cost-effective massively parallelized targeted sequencing for genomics, transcriptomics, and single cell analysis
Fatma Uzbas, Helmholtz Zentrum Munich
T15 - Reconstructing hematopoietic organization from longitudinal tracking of individual clones
Ingmar Glauche, Inst. f. Med. Informatics and Biometry (IMB), TU Dresden
16:00 - 16:30
Coffee break / Industry exhibition
Axon 2
16:30 - 17:30
GSCN General membership meeting
17:30 - 19:30 Poster session I

Even numbers: please present your poster from 17:30 - 18:30
Odd numbers: please present your poster from 18:30 - 19:30
19:45 - 20:30
Lecture hall
Keynote lecture III
K3 - Human germ line therapy
Shoukhrat Mitalipov, Oregon Health & Science University (OHSU), Portland, US (Chair: tbd)
20:30 - 22:00 Informal GSCN get together for all participants 
with dinner buffet in the MDC foyer

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Tuesday, 24 September

09:00 - 10:30
Concurrent scientific working group session II   
Axon 1
09:00 - 10:30
09:00 - 09:30

09:30 - 09:45


09:45 - 10:00


10:00 - 10:15


10:15 - 10:30
Stem cells in disease modeling and drug development
(Chairs: Oliver Brüstle / Karl-Ludwig Laugwitz)
T16 - iPSC-based modeling of metabolic disorders
Alessandro Prigione, Max Delbrück Center (MDC) Berlin
T17 -When neurodevelopment meets neurodegeneration - the crucial roles of ATP6AP2 for neural stem cells
Matthias Groszer, INSERM Paris, France
T18 - Recapitulating early embryonic heart development with human pluripotent stem cells
Lika Drakhlis, Hannover Medical School (MHH)
T19 - Exploring LZTR1-associated Noonan Syndrome in patient-specific and CRISPR corrected iPSC-derived cardiomyocytes
Lukas Cyganek, University Medical Center, Göttingen
T20 - Modeling the pathological long-range regulatory effects of human structural variation with patient-specific hiPSCs
Magdalena Laugsch, Institute of Human Genetics, University Hospital, Heidelberg
Axon 2
09:00 - 10:30
09:00 - 09:30


09:30 - 09:45


09:45 - 10:00


10:00 - 10:15



10:15 - 10:30
Stem cells in diseases: cancer stem cells
(Chairs: Hartmut Geiger / Andreas Trumpp)
T21 - Acute myeloid leukemia stem cells selectively evade immune surveillance by natural killer cells
Claudia Lengerke, University Basel, Switzerland
T22 - SFRP1 deficiency-induced alterations in the bone marrow niche enable development of malignant cells
Franziska Hettler, TU Munich
T23 - Wnt-induced phenotypic switch in cancer-associated fibroblasts inhibits EMT in colorectal cancer
Henner Farin, DKTK/Georg-Speyer-Haus, Frankfurt
T24 - Defined subsets of functional endogenous LINE-1 loci that mobilize in human epithelial tumors are activated and mobilized in human embryonic and induce pluripotent stem cell lines
Gerald Schumann, Paul Ehrlich Institute (PEI), Langen
T25 - Parent-of-origin effects in retinoblastoma in an in vitro stem cell model
Julia Menges, Institute of Human Genetics, University Hospital Essen
10:30 - 11:00
Coffee break / Industry exhibition
11:00 - 12:30
Industry session: "Technologies from GSCN industry partners"
Axon 1
11:00 - 12:30
11:00 - 11:30

11:30 - 12:00


12:00 - 12:30
Main supporter (Chair: Andreas Kurtz)

C1 - How to design and optimize your stem cell bioprocess
Philipp Nold, Eppendorf AG

C2 - Clonal dynamics of hematopoietic reconstitution after stem cell transplantation
Kerstin Cornils, UKE Hamburg representing PeproTech GmbH 
C3 - Bridging the bench-to-bedside abyss: concepts for manufacturing of ATMPs
Sebastian Knöbel, Miltenyi Biotech

Axon 2
11:00 - 12:30
11:00 - 11:30



11:30 - 12:00

12:00 - 12:30
Supporter (Chair: Andreas Trumpp)

C4 - MultiPL’: A standardized, characterized and virally inactivated human platelet lysate for the optimized and reproducible expansion of cell therapy products
Bruno Delorme, Macopharma
C5 - NutriFreez and cryopreservation: keeping it cool,
Oren Ben Yosef, Biological Industries (BI), Ltd./neofroxx
C6 - Innovative stem cell tools to simplify liver disease modelling studies using hiPS cells
Jenny Johannisson, Takara Bio Europe
Dendrit 2+3
11:00 - 12:30
11:00 - 11:30


11:30 - 12:00


12:00 - 12:30
Supporter (Chair: Frank Edenhofer)

C7 - Superior expansion human HSCs with StemPro™ HSC Expansion Medium and efficient genetic tagging of CD34+ cells with TrueTag system
Mohan Vermuri, Thermo Fisher Scientific 
C8 - Correction of heterozygous SHOX2 mutations in iPSCs via CRISPR/Cas and sib-selection
Simon Sumer (University Heidelberg), representing NIPPON Genetics Europe GmbH

C9 - Highly efficient and standardized tools to establish and maintain organoid cultures
Katharina Debowski, STEMCELL Technologies GmbH

12:30 - 14:00 Lunch break / Industry exhibition / Poster viewing  
12:45 - 13:45 Meet-the-expert tables (limited to 10 registered participants each)
Claudia Lengerke, University Basel; Shoukhrat Mitalipov, OHSU Portland; Jim Wells, Cincinnati Children’s Hospital Medical Center

Axon 1+2
   
14:00 - 16:15
Presidential Symposium
Chair: Hartmut Geiger
 
14:00 - 14:45 
Keynote
PS1 - Pancreas organoids to study human development and disease
Anne Grapin-Botton, MPI for Molecular Cell Biology and Genetics, Dresden

14:45 - 15:15 
Young Investigator Award 2018
PS2 - tba

15:15 - 15:45 
Female Scientist Award 2018
PS3 - tba

15:45 - 16:15 
Publication of the Year 2018 Award
PS4 - tba

16:15 - 16:30
Coffee break / Industry exhibition
 
16:30 - 18:30 Poster session II: 

Even numbers: please present your poster from 16:30 - 17:30
Odd numbers: please present your poster from 17:30 - 18:30

19:00 - 01:00
GSCN Networking evening for all participants
with dinner buffet at Spreespeicher, Oberbaumbrücke



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Wednesday, 25 September


09:00 - 10:30
Concurrent scientific working group session III  
Axon 1
09:00 - 10:30
09:00 - 09:30

09:30 - 09:45


09:45 - 10:00



10:00 - 10:15



10:15 - 10:30

Stem cells in regenerative therapies
(Chairs: Richard Schäfer / Wolfgang Wagner)
T26 - tba,
Alex Schambach, Hannover Medical School (MHH)
T27 - Direct lineage conversion enables the generation of epigenetically rejuvenated donor cells for neurotransplantation
Lea Jessica Flitch, Inst. for Reconstructive Neurobio., University of Bonn
T28 - In vitro stabilization of cardiac neural crest progenitor cells from hPSCs in defined culture conditions display multi-lineage and proliferative potential
Emiliano Bolesani, Hannover Medical School (MHH)
T29 - Muscle stem cell necroptosis is required for efficient regeneration in chronic regenerative disease
Johnny Kim, MPI for Heart and Lung Research, Bad Nauheim
T30 - Chemically-defined, biomimetic matrices for serum-free culture of MSC, iPSC and beyond
Richard Wetzel, denovoMATRIX GmbH, Dresden 
Axon 2
09:00 - 10:30
09:00 - 09:30


09:30 - 09:45



09:45 - 10:00


10:00 - 10:15


10:15 - 10:30
Hematopoietic stem cells
(Chairs: Elvira Mass / Claudia Waskow)
T31 - Haematopoietic stem cells and their malignant counterparts: Home is where the bone is
Daniela Krause, Georg-Speyer-Haus, Frankfurt
T32 - Hem1 loss destabilizes WAVE complex in hematopoietic cells with severe consequences for murine immature hematopoiesis
Eliza Wiercinska, German Red Cross Blood Donor Service Baden-Wuerttemberg-Hesse, Frankfurt
T33 - Transposable elements enhance hematopoietic regeneration via activation of innate immune signalling
Eirini Trompouki, MPI of Immunobiology and Epigenetics, Freiburg
T34 - Microenvironmental SFRP1 regulates hematopoietic stem cells repopulation via CTNNB1-CBP linked cell fate
Rouzanna Istvanffy, TU Munich
T35 - The association of somatic mutations in hematopoietic stem cells leading to clonal hematopoiesis with chronic ischemic heart failure
Michael Rieger, Goethe University, Frankfurt
Dendrit 2+3
09:00 - 10:30
09:00 - 09:30

09:30 - 09:45


09:45 - 10:00



10:00 - 10:15



10:15 - 10:30

Somatic stem cells and development
(Chairs: Federico Calegari / Ana Martin-Villalba)
T36 - tbd
tbd
T37 - Centrosome and microtubule dynamics regulate the balance of stem cell self-renewal and differentiation
Germán Camargo Ortega, ETH Zurich, Basel, Switzerland
T38 - Derivation and characterisation of human primordial germ cell-like cells and male specific differentiation in a novel xeno-organoid approach
Eva Maria Mall, MPI for Molecular Biomedicine, Münster
T39 - Prox1-positive endocrine cells monitor and sustain the intestinal epithelial cholinergic niche
Moritz Middelhoff, TU Munich
T40 - Transcriptional and epigenetic landscape of the mouse intestine during aging
Francesco Neri, Leibniz Institute on Aging (FLI), Jena
10:30 - 11:00 
Coffee break / Industry exhibition
11:00 - 12:30 Concurrent strategic working group session  
Axon 1
11:00 - 12:30
11:00 - 11:30


11:30 - 12:30
Career development
(Chairs: Marieke Essers / Insa Schröder)
S1 - Advance your professional career: how to benefit from opportunities in biopharmaceutical consulting
Diane Seimetz, Biopharma Exellence, Munich
S2 - How to develop the soft skills required for my career?
Neli Petkova, Talent Garden Coaching, Tübingen
 
Axon 2
11:00 - 12:30
11:00 - 11:30

11:30 - 12:00


12:00 - 12:30
Technologies in stem cell research
(Chairs: Andreas Bosio / Frank Emmrich)
S3 - Three-photon microscopy for ultra-deep intravital imaging
Raluca A. Niesner, Deutsches Rheuma-Forschungszentrum (DRFZ), Berlin
S4 - Cyclic multiplex immunofluorescence and spatial analysis in breast cancer subtypes
Jenny Eng, Oregon Health & Science University, Portland, USA 
S5 - Whole organs labeling and mapping with lightsheet microscopy and iDISCO+ clearing
Alba Vieites Prado, Institut du Cerveau et de la Moelle Epinière (ICM), Paris, France
 
Dendrit 2+3
11:00 - 12:30
11:00 - 11:30

11:30 - 12:00


12:00 - 12:30
Clinical trials and regulatory affairs
(Chairs: Zoltan Ivics / Hans-Dieter Volk)
S6 - tba
Alessandro Aiuti, Hospital San Rafaele, Milan, Italy
S7 - Next-generation regulatory T-cell products - opportunities and challenges
Hans-Dieter Volk, BIH Center for Regenerative Therapies (BCRT), Berlin
S8 - Extracellular vesicles: nano-sized all-rounders
Dirk Strunk, Paracelsus Medical University (PMU), Salzburg, Austria
12:30 – 14:00
Lunch break / Industry exhibition / Poster viewing
12:45 - 13:45 Meet-the-expert tables (limited to 10 registered participants each)
Marieke Essers, DKFZ Heidelberg (tbc); Anne Grapin-Botton, MPI Dresden; Pekka Katajisto, University Helsinki (tbc)
Axon 1+2

14:00 - 14:45
Keynote lecture IV
K4 - tba
Lorenz Studer, Memorial Sloan Kettering Cancer Center, New York, US
(Chair: Ana Martin-Villalba)
14:45 - 15:30 Keynote lecture V
K5 - tba
Pekka Katajisto, University of Helsinki, Finland 
(Chair: Ana Pombo)
 
15:30 - 15:50   Poster award ceremony
Daniel Besser
 
15:50 - 16:00
Closing remarks by the GSCN president 
Hartmut Geiger
End of GSCN conference 2019
 
Announcement:
18:30 – 21:00  GSCN Public outreach event with panelists (in German)

 

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