GSCN Awardees 2023

The "GSCN 2023 Young Investigator Award" goes to Meike Hohwieler from the Institute of Molecular Oncology and Stem Cell Biology at Ulm University Hospital.

The "GSCN 2023 Hilde Mangold Award" goes to Anne Grapin-Botton from the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) in Dresden.

The "GSCN 2023 Publication of the Year Award" goes to Ruzhica Bogeska, ... Michael D. Milsom from Division of Experimental Hematology, German Cancer Research Center (DKFZ) & HI-STEM, receive the GSCN 2023 Publication of the Year Award for the publication “Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging” in the journal Cell Stem Cell, Aug. 2022.

Find the GSCN press release here:  
Finden Sie die Pressemitteilung auf Deutsch hier: 

GSCN 2023 Young Investigator Award

Dr Meike Hohwieler from Ulm University Hospital receives the GSCN 2023 Young Investigator Award from the German Stem Cell Network (GSCN). The stem cell biologist conducts research on the early development of pancreatic diseases.
In her research at the Institute of Molecular Oncology and Stem Cell Biology at Ulm University Hospital, Meike Hohwieler develops pancreatic organoids from pluripotent stem cells. These models serve to deepen the still largely unknown understanding of the developmental biological processes of both the healthy human pancreas and its diseases. Organoids reproduce the developmental steps of human cells much more adequate than mouse models and can thus also partially replace animal experiments. For this purpose, Hohwieler developed a kind of cell chip which an read the early developmental stages of the cells and which enables a systematic development of the pancreatic organoids. Her findings pave the way for innovative possibilities in the early detection of pancreatic carcinomas as well as diabetes. Pancreatic cancer is a cancer that is often detected very late, is very heterogeneous and has an exceedingly poor prognosis: Five years after the diagnosis, only twelve percent of patients are still alive.

Meike Hohwieler completed her Master studies in Molecular Biotechnology at the Technical University of Munich and joined the lab of Alexander Kleger at the Ulm University hospital in 2012. Here, she participated in the International PhD program in Molecular Medicine of Ulm University and obtained the doctoral degree with her work on “Human Pluripotent Stem Cell-​derived Pancreatic Organoids to Study Cystic Fibrosis in a Dish”.

 

Meike Hohwieler 

 

GSCN 2023 Hilde Mangold Award

Anne Grapin-Botton receives the GSCN 2023 Hilde Mangold Award for her many years of significant research on organoids of the pancreas in animal models and in human tissue. Currently, the French scientist and her research group at the MPI of Molecular Cell Biology and Genetics (MPI-CBG) is focusing on pancreas development with the overall goals of understanding how pancreatic cells differentiate during embryogenesis, and determining what limits the pancreatic cells’ regeneration in adults. Grapin-Botton investigates the impact of the cellular and organ architecture on the cells’ fate choices and the dynamics of decision processes. Anne Grapin-Botton has a background in developmental biology and initially studied nervous system and endoderm development. 

Anne Grapin-Botton (*1967) studied biology at the UPMC University Pierre and Marie Curie (Paris VI) and graduated in 1991 in molecular and cellular pharmacology. In 1995, she obtained her PhD there with a research focus on brain development, followed by years as postdoctoral researcher at Harvard University (Cambridge, USA). In 2001, she became research group leader of the Pancreas Development and Cancer Group at ISREC (Swiss Institute for Experimental Cancer Research) and then at EPFL (Ecole Polytechnique Fédérale de Lausanne, Switzerland). In 2012, she moved to the Danish Stem Cell Center at the University of Copenhagen as Professor of Developmental Biology. Anne Grapin-Botton has been Director at the MPI-CBG since August 2018. 



Anna Grapin-Botton

GSCN 2023 Publication of the Year
Ruzhica Bogeska, ... Michael D. Milsom from Division of Experimental Hematology, German Cancer Research Center (DKFZ) & HI-STEM,
receive the GSCN 2023 Publication of the Year Award for the publication “Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging” in the journal Cell Stem Cell, Aug. 2022.
The manuscript examines the long-term consequences of inflammation and infection challenge on hematopoietic stem cells, leading to the surprising observation that these stem cells never functionally recover from such challenges. This data supported a model where the inhibitory effect of such challenges can accumulate during an individual’s lifetime, even if the exposure to such agonists is separated by weeks, months or even years. In support of this hypothesis, mice exposed to inflammatory challenge in early to mid-life demonstrated an accelerated hematologic aging phenotype and developed features of normal human aged hematopoiesis that are not routinely observed in laboratory mice.
At the GSCN Conference 2023 in Ulm, Ruzhica Bogeska will give the award lecture on 14 September.

Publication: 
Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging in the journal Cell Stem Cell, Aug. 2022


 

GSCN Awards 2023

The GSCN awards each year three prize winners in the following sections:
"GSCN 2023 Young Investigator Award
"GSCN 2023 Hilde Mangold Award
"GSCN 2023 Publication of the Year Award
The awardees will give a lecture in the Presidential Symposium on Thursday, 14 Sept. 2023, at this year's GSCN Conference in Ulm.
Deadline for candidate proposals is 3 July 2023.

If you want to propose a candidate for the GSCN 2023 Hilde Mangold Award, please use this form.
If you want to propose a candidate for the GSCN 2023 Young Investigator Award, please use this form.
If you want to suggest a Publication of the Year 2022-2023, please write a mail to gscn.office@mdc-berlin.de.

GSCN Awardees 2021

The "GSCN 2021 Young Investigator Award" goes to Elvira Mass from the Life and Medical Sciences Institute (LIMES) at the University of Bonn.
The "GSCN 2021 Hilde Mangold Award" goes to Katja Schenke-Layland from the Natural and Medical Sciences Institute at the University of Tübingen.
The "GSCN 2021 Publication of the Year Award" goes to Katharina Scheibner and Heiko Lickert together with Silvia Schirge and Ingo Burtscher from the Institute of Diabetes and Regeneration Research at Helmholtz Zentrum München.

Find the GSCN press release here:  Revealing secrets of embryonic development

"GSCN 2021 Young Investigator Award"

Prof. Dr. Elvira Mass receives the "GSCN 2021 Young Investigator Award" for her outstanding research in the field of the developmental significance of macrophages as cells of the innate immune system. Mass showed that macrophages, so-called big eaters, are long-lived and are an integral part of organogenesis. When mutated, they can initiate maldevelopments, e.g., in the brain, and play a decisive role in later diseases. Thus, Mass is changing the understanding of macrophages in their role in embryonic organ development and their influence on disease ontogeny and progression.

Elvira Mass (35) studied biology at the University of Bonn and earned her doctorate at the Life and Medical Sciences Institute (LIMES). In 2014, she joined Frederic Geissmann's lab at King's College in London and followed him a few months later to Memorial Sloan-Kettering Cancer Center in New York. From there, she returned to the LIMES Institute at the University of Bonn in 2017 as a group leader. In 2019, she became a professor for "Integrated Immunology" at the University of Erlangen-Nürnberg. In 2020, she moved to a professorship at the LIMES Institute. Mass has received several awards, including the Heinz Maier Leibnitz Prize in 2020 and the Paul Ehrlich and Ludwig Darmstaedter Young Investigator Award in 2021.

Elvira Mass 

 

"GSCN 2021 Hilde Mangold Award"
 

Prof. Dr. Katja Schenke-Layland receives the "GSCN 2021 Hilde Mangold Award" for her significant research on the translation of findings from early human development into applications for regenerative medicine with a special focus on the extracellular matrix. Her career as a scientist and science manager shows a path of success that could be exemplary and inspiring for young women researchers: After studying biology and completing her doctorate in Jena, Katja Schenke-Layland moved to the USA, first as a postdoc and later as an assistant professor in Los Angeles, for in-depth research on cardiovascular tissue. From 2010, she took on various leadership positions in Germany at the Fraunhofer Institute for Interfacial Engineering and Biotechnology in Stuttgart, while also being an Associate Professor at UCLA in Los Angeles and, from 2011, Professor of Medical Engineering and Regenerative Medicine at the Medical Faculty of the Eberhard Karls University in Tübingen. Since 2018, she has been the Director at the NMI Natural and Medical Sciences Institute in Reutlingen.



Katja Schenke-Layland

"GSCN 2021 Publication of the Year"

Katharina Scheibner and Heiko Lickert receive the "GSCN 2021 Publication of the Year Award" together with Ingo Burtscher and Silvia Schirge for their joint publication "Epithelial cell plasticity drives endoderm formation during gastrulation", published 2021 in Nature Cell Biology. The scientists from the Institute of Diabetes and Regeneration Research at Helmholtz Zentrum München gained new insights into the formation of the endoderm cotyledon during gastrulation, the first phase of embryonic development. The researchers show that the formation of the endoderm cotyledon is regulated by the plasticity of the epithelial cells. This allows the cells to leave the epithelium and migrate away. This is important not only to understand how a fertilized egg becomes a whole organism, but especially to understand how hereditary diseases develop. This understanding could help improve cell replacement therapies. (Scheibner, Schirge, Burtscher et al., 2021: Epithelial cell plasticity drives endoderm formation during gastrulation. Nature Cell Biology, DOI: 10.1038/s41556-021-00694-x)


Publication: Scheibner, Schirge, Burtscher et al., 2021: Epithelial cell plasticity drives endoderm formation during gastrulation. Nature Cell Biology, DOI: 10.1038/s41556-021-00694-x


Katharina Scheibner


Silvia Schirge


Heiko Lickert


Ingo Burtscher

GSCN Hilde Mangold Award

Awarded annually, the GSCN Female Scientist Award has now been rebranded as the GSCN Hilde Mangold Award. The new name is in recognition of German embryologist Hilde Mangold (born October 20, 1898, in Gotha; died September 4, 1924, in Berlin). Mangold performed key experiments which paved the way for the discovery of the embryonic organizer, thereby playing a seminal role in the development of embryology. Her early death in a tragic accident prevented her from being honored together with Hans Spemann when the latter was awarded the Nobel Prize for the discovery of the organizer effect in 1935.
The annual GSCN science prize is bestowed on outstanding female stem cell researchers. In addition to scientific achievement, the jury also aims to recognize the award winner’s lifetime achievement as a role model for young female scientists. As before, women continue to be underrepresented in stem cell research leadership positions at universities and research institutes.

Contact

Please contact Stefanie Mahler for more information or pictures of the awardees.

Stefanie Mahler
Stefanie Mahler
Communication


phone: +49 (0)30 9406 2483
e-mail: stefanie.mahler@mdc-berlin.de

Past GSCN Awardees

Find all related information here.

2022:
GSCN 2022 Young Investigator Award:
Simon Haas
GSCN 2022 Hilde Mangold Award:
Meritxell Huch
GSCN 2022 Publication of the Year:
Adam C. O’Neill, Fatma Uzbas, Giulia Antognolli, Florencia Merino, Magdalena Götz

2021:
GSCN 2021 Young Investigator Award:
Elvira Mass
GSCN 2021 Hilde Mangold Award:
Katja Schenke-Layland
GSCN 2021 Publication of the Year:
Katharina Scheibner, Heiko Lickert, Ingo Burtscher, Silvia Schirge

2020:
GSCN 2020 Young Investigator Award:
Barbara Treutlein
GSCN 2020 Female Scientist Award:
Edith Heard
GSCN 2020 Publication of the Year:
Sergiy Velychko and Hans R. Schöler

2019:
GSCN 2019 Young Investigator Award:
Nico Lachmann 
 GSCN 2019 Female Scientist Award:
Ana Martin-Villalba
GSCN 2019 Publication of the Year:
Germán Camargo Ortega and Magdalena Götz

2018:
GSCN 2018 Young Investigator Award:
Nina Cabezas-Wallscheid
GSCN 2018 Female Scientist Award:
Maria Elena Torres-Padilla
GSCN 2018 Publication of the Year:
Maja Milanovic and Clemens Schmitt

2017:
GSCN 2017 Young Investigator Award:
Francesco Neri
GSCN 2017 Female Scientist Award:
Elly Tanaka
GSCN 2017 Publication of the Year:
J. Gray Camp, Keisuke Sekine, Takanori Takebe and Barbara Treutlein

2016:
GSCN 2016 Young Investigator Award:
Leo Kurian
GSCN 2016 Female Scientist Award:
Claudia Waskow
GSCN 2016 Publication of the Year Award:
Guangqi Song, Martin Pacher, Michael Ott and Amar Deep Sharma

2015:
GSCN 2015Young Investigator Award:
Julia Ladewig 
GSCN 2015 Female Scientist Award:
Magdalena Götz 
GSCN 2015 Publication of the Year Award:
Jichang Wang and Zsuzsanna Izsvák 
 

 

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