Program

Wednesday Thursday  Friday

Wednesday, 19 September

Lecture hall
Joined Session with Behr Symposium
Chair: Andreas Trumpp / Nina Cabezas-Wallscheid
09:00 - 09:25
T01 - Transcriptional and epigenetic control of cardiogenesis
Gergana Dobreva, Medical Faculty Mannheim, Uni. Heidelberg
09:25 - 09:45 T02 - Organ topology splits homeostatic and growth stem cells in fish
Lázaro CentaninCentre for Organismal Studies (COS), Uni. Heidelberg
09:45 - 10:30 Keynote lecture I
K1 - Tracking HSC self-renewal and differentiation in the niche
Leonard Zon, Harvard Department of Stem Cell and Regenerative Biology, Cambridge, US
10:30 - 11:00  Coffee break / Industry exhibition / Registration
Lecture hall
Opening 
11:00 - 11:20 Welcome to German Cancer Research Center, Heidelberg
11:20 - 11:30 GSCN Annual Conference 2018
Ana Martin-Villaba, President GSCN
11:30 - 12:15 
Keynote lecture II
K2 - Global views of development: Reconstructing trajectories and lineages
Alex Schier, Havard University, Cambridge, US
(Chair: Lázaro Centanin)
12:15 - 13:00 Keynote lecture III
K3 - tba
William Pu, Harvard Stem Cell Institute, Cambridge, US
(Chair: Gergana Dobreva)
13:00 - 14:30
Lunch break / Industry exhibition
14:30 - 16:00 Concurrent scientific working group session I
Lecture hall
14:30 - 15:00


15:00 - 15:12


15:12- 15:24


15:24 - 15:36


15:36 - 15:48


15:48 - 16:00
Technobeat workshop (Chairs: Robert Zweigerdt / Dirk Strunk)
T03 - Special keynote: Human embryonic stem cell-derived cardiomyocytes regenerate the infarcted pig heart
Michael Laflamme, Toronto General Hospital Research Institute, Canada
T04 - Chemically defined cardiomyogenic differentiation of human pluripotent stem cells in bioreactors
Caroline Halloin, Hannover Medical School
T05 - Aiming for increased retention of cardiac cell aggregates in a porcine model of myocardial infarction
Evelyne Demkes, UMC Utrecht, Netherlands
T06 - Development of immunosuppressive iPSC-derived stromal cells for tissue regeneration
Patricia Peking, Paracelsus Medical University, Salzburg, Austria
T07 - Human stem cell-derived cardiac fibroblasts enhance structural and functional cardiomyocyte maturation in a three-dimensional microtissue environment
Elisa Giacomelli, Leiden University Medical Center, Netherlands
T08 - The detection and minimisation of genetically variant stem cells in human pluripotent stem cell cultures
Jason Halliwell, Uni. Sheffield, U.K.
Room I & II
14:30 - 15:00


15:00 - 15:15


15:15- 15:30


15:30 - 15:45


15:45 - 16:00
Computational stem cell biology (Chairs: Georg Füllen / Ingo Röder)
T09 - Special keynote: Dynamics of T cell memory generation inferred from single cell fate mapping in vivo
Michael Floßdorf, TU Munich
T10 - Divisional behaviour of haematopoietic stem cells revisited: insights from a mathematical model of in vivo label dilution
Thomas Zerjatke, TU Dresden
T11 - Unidirectional and progressive DNA methylation changes define hematopoietic lineage commitment
Sina Stäble, German Cancer Research Center, Heidelberg
T12 - Reconstruction of haematopoetic differentiation trajectory using Triplet-network
Tingying Peng, HelmholtzZentrum Munich
T13 - A web application for predicting cell-fate determinants in cell differentiation
Andras Hartmann, Luxembourg Center for Systems Biomedicine
LH Marsilius Kol.

14:30 - 15:00


15:00 - 15:15


15:15- 15:30


15:30 - 15:45


15:45 - 16:00
Stem cells in disease: cancer stem cells (Chairs: Thomas Brabletz / Michael Rieger)
T14 - Special keynote: A molecular subtype of cancer originating from adult stem cells during regeneration is driven by Dux transcription factors
Johnny Kim, MPI-HLR, Bad Nauheim
T15 - Orchestration of stem- and EMT-like phenotypes during tumor initiation and progression
Oguzhan Kaya, German Cancer Research Center, Heidelberg
T16 - Unbiased identification of tumour suppressor function by pooled CRISPR/Cas9 screening in human colon organoids
Henner Farin, Georg-Speyer-Haus, Frankfurt
T17 - The microRNA-371~373 cluster represses colon cancer initiation and metastatic colonization by inhibiting the TGFBR2/ID1 signaling axis
Elisabeth Letellier, Uni. Luxembourg
T18 - High Transglutaminase 2 activity is a poor prognostic marker in colorectal carcinoma and essential for cell survival and stemness
Ilaria Lunger, Goethe Uni. Hospital, Frankfurt
16:00 - 16:30
Coffee break / Industry exhibition
Room I & II
16:30 - 17:30
GSCN General membership meeting
17:30 - 19:30 Poster session I
Even numbers: please present your poster from 17:30 - 18:30
Odd numbers: 18:30 - 19:30
19:45 - 20:30
Lecture hall
Keynote lecture IV
K4 - The blastoid: Blastocyst-like structures generated solely from stem cells
Nicolas Rivron, Hubrecht Institute, Utrecht, Netherlands (Chair: Tobias Cantz)
20:30 - 22:00 Informal GSCN get together for all participants
with dinner buffet at the foyer

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Thursday, 20 September

09:00 - 10:30
Concurrent scientific working group session II   
Lecture hall

09:00 - 09:30


09:30 - 09:45


09:45 - 10:00


10:00 - 10:15


10:15 - 10:30
Stem cells in disease modelling and drug development (Chairs: Oliver Brüstle / Bert Klebl)
T19 - Special keynote: Pluripotent stem cell models of human heart disease
Karl-Ludwig Laugwitz. TUM School of Medicine, Munich
T20 - Recapitulation of plaque formation, tau pathology and neurodegeneration in a human 3D model of Alzheimer’s disease
Matthias Hebisch, Institute for Reconstructive Neurobiology, Uni. Bonn
T21 - Neural retina differentiation of hESCs as an in vitro model for retinoblastoma
Julia Menges, Institute of Human Genetics, University Hospital Essen
T22 - IndivuHeart – Risk assessment for heart diseases with patient-specific iPSC-derived engineered heart tissue
Bärbel Ulmer, University Medical Center Hamburg-Eppendorf (UKE)
T23 - A coherent roadmap to generate either pancreatic acinar or duct-like cells from human pluripotent stem cells challenges pancreatic cancer biology
Meike Hohwieler, Internal Medicine I, Ulm University Hospital
Room I&II

09:00 - 09:30


09:30 - 09:45


09:45 - 10:00



10:00 - 10:15


10:15 - 10:30
Pluripotency and Re-programing (Chairs: Hans Schöler / Mathias Treier)
T24 - Special keynote: tba
Andras Nagy, Lunenfeld-Tanenbaum Research Institute,  Mount Sinai Hospital, Toronto, Canada
T25 - Reprogramming factor promiscuity requires co-factors to ensure cell fate specificity
Moritz Mall, German Cancer Research Center, Heidelberg
T26 - Genome-wide analyses of LINE-1 (L1) integromes in human induced pluripotent stem cells uncover insertional bias for active transcriptional start sites
Gerald Schumann, Paul Ehrlich Institute, Langen
T27 - Expanded potential stem cells (EPSCs) derived from porcine embryos contribute to porcine development in vivo
Monika Nowak-Imialek, Hannover Medical School
T28 - Identification of embryonic neural border stem cells and its generation by direct reprogramming from human blood
Marc Christian Thier, German Cancer Research Center, Heidelberg
10:30 - 11:00
Coffee break / Industry exhibition
11:00 - 12:30
Industry session: "Technologies from GSCN industry partners"
Lecture hall
11:00 - 11:45

11:45 - 12:30
Main supporter (Chair: Michael Cross)
C1 - tba
tba, Eppendorf AG
C2 - Large-scale production of induced pluripotent stem cells-derived megakaryocytes in bioreactors
Constanca Figueiredo, Hannover Medical School representing PeproTech GmbH
Room I&II
11:00 - 11:30

11:30 - 12:00

12:00 - 12:30
Supporter (Chair: Hartmut Geiger)
C3 - tba
tba, Takara Bio Europe, SAS
C4 - tba
Sebastian Knöbel, Miltenyi Biotec GmbH
C5 - Removing inherent bottlenecks in the genome engineering of iPSCs to build relevant disease models for target and compound screening
Jon Chesnut, Thermo Fisher Scientific
LH Marsilius Kol.
11:00 - 11:30


11:30 - 12:00
Supporter (Chair: Ulrich Martin)
C6 - Considerations for serum-free, xeno-free media for stem cell applications
Suzanne Badoux, Biological Industries (BI), Ltd.
C7 - Organoids are complex, growing them shouldn’t be: Efficient, standardized tools for organoid culture
Katharina Debowski, STEMCELL Technologies GmbH
12:30 - 14:00 Lunch break / Industry exhibition / Poster viewing  
12:45 - 13:45 Meet-the-expert tables (limited to 10 registered participants each)
Gergana Dobreva, Medical Faculty Mannheim, Uni. Heidelberg; Lázaro Centanin, Centre for Organismal Studies (COS), Uni. Heidelberg

Lecture hall
   
14:00 - 16:15
Presidential Symposium
Chair: Ana Martin-Villalba
 
14:00 - 14:45 
Keynote
PS1 - Human glial progenitor cell-based treatment and modeling of neurological disease
Steve Goldman, University of Rochester Medical Center, US/Center for Translational Neuromedicine, Uni. Copenhagen, Denmark

14:45 - 15:15 
Female Scientist Award 2018
PS2 - Epigenetic mechanisms of cellular plasticity
Maria-Elena Torres-Padilla, Helmholtz Zentrum München, Munich

15:15 - 15:45 
Young Investigator Award 2018
PS3 - Regulation of dormant hematopoietic stem cells
Nina Cabezas Wallscheid, Max Planck Institute of Immunobiology and Epigenetics, Freiburg

15:45 - 16:15 
Publication of the Year 2018 Award
PS4 - Senescence-associated reprogramming promotes cancer stemness
Maja Milanovic, Charité, Berlin

16:15 - 16:30
Coffee break / Industry exhibition
 
16:30 - 18:30 Poster session II
Even numbers: please present your poster from 16:30 - 17:30
Odd numbers: 17:30 - 18:30

19:00 - 01:00
GSCN Networking evening for all participants
with dinner buffet and DJ at the Frauenbad



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Friday, 21 September


09:00 - 10:30
Concurrent scientific working group session III  
Lecture hall

09:00 - 09:30


09:30 - 09:45

09:45 - 10:00


10:00 - 10:15


10:15 - 10:30
Stem cells in regenerative therapies (Chairs: Ulrich Martin / Wolfgang Wagner)
T29 - Special keynote: Photoreceptor transplantation into the mammalian retina
Marius Ader, Center for Regenerative Therapies (CRTD), TU Dresden
T30 - Thyroid hormone signaling controls zebrafish brain regeneration
Michael Brand, Center for Regenerative Therapies (CRTD), TU Dresden
T31 - Two succeeding fibroblastic lineages drive dermal development and the transition from regeneration to scarring
Yuval Rinkevich, HelmholtzZentrum Munich
T32 - Investigation of the role of pericytes in the in vitro model of bioartificial tissue formation from hPSC-derived cardiovascular cell types
Monika Szepes, Hannover Medical School
T33 - Hematopoietic stem cell gene therapy for Ifngr1-deficiency highlights role of macrophages in mycobacterial infections and paves way for macrophage transplantation therapy
Kathrin Haake, Hannover Medical School
Room I & II
09:00 - 09:30


09:30 - 09:45



09:45 - 10:00



10:00 - 10:15




10:15 - 10:30

Hematopoietic stem cells (Chairs: Timm Schroeder / Claudia Waskow)
T34 - Special keynote: Impact of inflammation on hematopoietic stem cells
Mick Milsom, German Cancer Reserach Center, Heidelberg
T35 - Cell-extrinsic and -intrinsic regulation of PU.1 in HSC lineage choice
Nouraiz Ahmed, Department of Biosystems Science & Engineering, ETH Zurich/Basel, Switzerland
T36 - Combined single-cell and spatial transcriptomics to deconvolute the hematopoietic and mesenchymal stem cell niche
Simon Haas, German Cancer Reserach Center, Heidelberg
T37 - P53 prevents malignant transformation of hematopoietic stem cells by forcing their entry into the cell cycle and apoptosis in response to DNA damage
Andreas Brown, Institute for Molecular Medicine, Uni. Ulm
T38 - Functional dominance of CHIP-mutated hematopoietic stem cells in patients undergoing autologous stem cell transplantations
Lena Dorsheimer, University Hospital, Goethe University, Frankfurt
LH Marsilius Kol.

09:00 - 09:30




09:30 - 09:45




09:45 - 10:00




             
10:00 - 10:15




10:15 - 10:30

Somatic stem cells and development (Chairs: Thomas Braun / Federico Calegari)
T39 - Special keynote: Beta cell development, heterogeneity and regeneration
Heiko Lickert, Institute of Diabetes and Regeneration Research, HelmholzZentrum Munich
T40 - Endoderm formation does not require a mesendoderm progenitor stage and is independent from Brachyury function
Silvia Engert, Institute of Diabetes and Regeneration Research, HelmholzZentrum Munich
T41 - DNA methylation changes during culture expansion of mesenchymal stromal cells are strand-specific and reflect changes in chromatin conformation
Julia Franzen, Helmholtz-Institute for Biomedical Engineering, RWTH Aachen Medical School
T42 - Setting the gene regulatory landscape driving astrogliogenesis by stage-specific transcription factors
Neha Tiwari, Institute of Physiological Chemistry, University Medical Center, Mainz
T43 - Quiescence regulates the number of neural stem cells and their regenerative capacity in the aging brain
Georgios Kalamakis, German Center Research Center, Heidelberg
10:30 - 11:00 
Coffee break / Industry exhibition
11:00 - 12:30 Concurrent strategic working group session  
Lecture hall
Career development (Chairs: Hartmut Geiger / Insa Schröder)
S1 - Mobbing at the workplace: Effective solutions for livable working environments / Mobbing am Arbeitsplatz und wirksame Antworten für lebenswerte Arbeitskulturen (EN/DE)
Matthias Tholen, Tholen Beratung, Heidelberg
Annette Bornhäuser, Selbstcoaching, Heidelberg
 
Room I & II

11:00 - 11:30


11:30 - 12:00

12:00 - 12:30
Technologies in stem cell research - Microfluidics in stem cell research (Chairs: Andreas Bosio / tba)
S2 - tba
Agnete Kirkeby, University of Copenhagen, Denmark
S3 - tba
Nicola Elvassore, University of Padova, Italy
S4 - Microfluidic ipSC-derived human autologous Multi-Organ-Chips
Anja Ramme, TissUse GmbH, Berlin
 
LH Marsilius Kol. 

11:00 - 11:30

11:30 - 12:00

12:00 - 12:30
Clinical trials and regulatory affairs (Chairs: Andreas Kurtz / Zoltan Ivics)
S5 - tba
Henrik SembUniversity of Copenhagen, Denmark
S6 -tba
Malte Tiburcy, University of Goettingen
S7 - Advanced Therapy Medicinal Products (ATMPs): What is needed for smooth transition from R&D to clinical development stage
Diane Seimetz, Biopharma Excellence GmbH, Munich
12:30 – 14:00
Lunch break / Industry exhibition / Poster viewing
12:45 - 13:45 Meet-the-expert tables (limited to 10 registered participants each)
Diane Seimetz, Biopharma Excellence GmbH, Munich; Andreas Trumpp, German Cancer Research Institute, Heidelberg; 
Lecture hall

14:00 - 14:45
Keynote lecture V
K5 - Genetic and epigenetic processes controlling adult stem cell behavior
Allison Bardin, Institut Curie, Paris, France
(Chair: tba)
14:45 - 15:30 Keynote lecture VI
K6 - Molecular control of stem cell and developmental potency
Jianlong Wang, Icahn School of Medicine at Mount Sinai, New York, US
(Chair: Jan Lohmann)
 
15:30 - 15:50   Poster award ceremony
Daniel Besser
 
15:50 - 16:00
Closing remarks by the incoming GSCN president 
Hartmut Geiger
End of GSCN conference 2018
 
Announcement:
18:30 – 21:00  GSCN Public outreach event with panelists (in German)

 

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Supporters